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Inhibition under Spontaneous Firing Induces Effective Synthronization among Neuronal Population

Takashi Shinozaki

 

Abstract

We investigated the novel synchronization phenomenon caused by weak inhibitory input. The synchronization effect of inhibitory synaptic inputs has been vastly investigated in many theoretical and physiological studies. It usually requires exceedingly strong inhibition which squashes the membrane potential to the reversal potential of inhibitory synapses. In this study, we exhibited weak inhibitory input is enough to synchronize neuronal population under spontaneous firing (Shinozaki et al., 2007 & 2010). When membrane potentials are close to the firing threshold, weak hyperpolarization totally closes half opened sodium channel. It reduces the degree of freedom for catching environmental noises, resulting synchronization of the membrane potential. The phenomena was validated both in numerical simulations and electrophysiological experiments in vitro.

Moreover, we applied the phenomenon for controlling the firing propagation in a feedforward neural network with biologically plausible parameters (Shinozaki et al., 2013).